Abstract
The rate of oxidation of alcohol in the tissues of rabbits (liver, brain, heart, kidneys and muscles) was determined. by the manometrical method as previously reported by the author. The concentration of alcohol added in tissue hemogenates was 0.4 %. The data indicated that the oxidation rates in the liver, brain and heart increase by 18%, 43% and 94% respectively after habituation. Discussing this data and the results described in literatures, the author concluded as follows : The activity of the enzyme system in brain appears to increase after habituation, without being inhibited by alcohol in higher concentration. It is, therefore, probable that the central nervous system of the habituated animals can oxidize more alcohol than that of the non-habituated and in addition utilize it as a energy source of cerebral activity.
