Abstract
The protective action of salicylates against anaphylactic responses (shock as well as Schulz-Dale reaction) on guinea pigs, which were sensitized actively with egg-albumin or passively with serum of rabbit treated with egg-albumin. Result : (1) In the case of the active sensitization, anaphylactic responses were inhibited and animals survived against challenge when a sufficient large dose of sodium salicylate or acetylsalicylic acid was given repeatedly during all stages or at the middle stage of sensitizing treatment. (2) Passive anaphylaxis was similarly interferred with sodium salicylate when a sufficient dose of the drug was applied at the proper stage, i.e. within 12 hours from the beginning of the sensitizing procedure. (3) In guinea pigs sensitized with rabbit anti-egg-albumin serum, which were treated preliminary with salicylates during a period more than 24 hoursin vitro, the anaphylactic death was not observed. (4) It could be supposed that the salicylates had no effect on the circulating antibody-level.
