Abstract
1) Rutin, quercetin and dihydroquercetin (D.H.Q.) give diuretic action to normal and hydrated rabbits. 2) The mode of diuretic action is different in rutin, quercetin and D.H.Q. respectively. D.H.Q. shows its action shortly after injection and rutin at a later stage, while quercetin shows its action at both early and later stages. 3) The diuretic action can be observed also in rats slightly. 4) The effects of combined use of rutin, quercetin and D.H.Q. with caffein, g-strophanthin, or Igrosin are not identical. Simultaneous application of quercetin with caffein or Igrosin; and D.H.Q. with Igrosin produce a synergistic diuretic action. The antidiuretic action of g-strophanthin is antagonized by the use of these flavone compounds. 5) These flavone compounds cause hydremia in rabbits. Quercetin shows the most marked action of these compounds. 6) These flavone compounds cause a slight fall in blood pressure, without causing any influence upon a kidney volume. 7) Quercetin accelerates the respiration of kidney slices of mice, while no evident action is observed in the case of rutin or D.H.Q.. 8) The combination of quercetin with caffeine, g-strophanthin or Igrosin and that of D.H.Q. with Igrosin increase the rates of respiration of kidney slices. But the combined application of rutin with caffein or g-strophanthin decreases the tissue respiration. 9) Rutin, quercetin. and D.H.Q. are rapidly excreted in urine. After intravenous injection, from 20-50% of administered rutin or quercetin can be recovered in the urine and from 10-20 % of D.H.Q
