Folia Pharmacologica Japonica
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
The influences of some drugs on the output of adrenaline and noradrenaline in the suprarenal gland
Tomio SEGAWA
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1954 Volume 50 Issue 6 Pages 536-549,en42

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Abstract
The investigation on the amounts of adrenaline (A) and noradrenaline (N) in the suprarenal gland and in the blood after administration of mecholyl, acetylcholine, nicotine and the splanchnic stimulation was performed. Rat's blood-pressure and rabbit's intestine were used to estimate the contents of A and N in the isolated rabbit's suprarenal gland, the Gaddum's formula being applied for calculation. The proportions of A and N liberated from the suprarenal gland were determined by the method. of Bülbring and Burn, using a denervated cat's nictitating membranes. Under the conditions mentioned above an increase of N and a decrease of A was observed. From these results it may be considered that N plays an important part as an adrenergic transmitter.
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