Abstract
The excised liver of guinea pig was perfused with blood and Ringer solution containing digitoxin and the digitoxin uptake of the liver was determined by assaying the potency of perfusion fluid and overflow using guinea pigs. The following conclusions were obtained : Digitoxin is gradually transferred to or absorbed by the liver from the fluid during perfusion by physiological activity of the liver itself, but not by diffusion. The extent of activity is suggested to be extremely large, since the maximal amount of digitoxin “captured” by the liver which was saturated with digitoxin, was calculated at 0.12 mg or over per gram liver.
