Abstract
1) Adopon was observed to have marked paralyzing action, anti-acetyl-cholinic and anti-histaminic action on the isolated intestine of rabbit and guinea pig. However, it is inferior to Banthine in anti-acetylcholinic action, but superior in anti-barium action. The action on the intestine in situ was fluctuating and uncertain. 2) Adopon exhibits inhibitory action on the isolated heart of the frog, but lesser degree. On the blood vessel it has dilatatory action and anti-adrenaline and anti-barium actions were also observed. 3) In the blood pressure and respiration tests with rabbit, the intravenous injection of less than 0.2 mg/kg Adopon did not show any appreciable effects, but the intravenous injection of 3.0-5.0 mg/kg showed marked fall of blood pressure and inhibitory action on respiration after transient stimulation. 4) It has paralyzing action on skeletal muscle of frog, but to a lesser degree as compared with its action on smooth muscle. 5) Adopon did not have any marked influence on the size of pupil of the rabbit eye or of the isolated eye of the frog. 6) The toxicity of Adopon in mice is relatively low; especially with the subcutaneous injection, the toxicity was observed to be much lower than with the intravenous injection.
