Abstract
The actions of laurifoline chloride, a quaternary ammonium base isolated from Cocculus laurifolius DC., were investigated in detail. Laurifoline showed predominant vasodepressive and very weak curarelike action. It was further proved that this alkaloid had marked nicotinolytic but no atropine-like, no muscarine-like, no histamine liberating, nor adrenolytic actions. It is worth noting that laurifoline is a natural alkaloid belonging to groups of drugs which exert the typical action of ganglion blocking agents.
