Pharmacological Studies of Oxazolazepam, a new Psychotropic Agent. (Report 2)

General pharmacology and subacute toxicity

Abstract

On cardiovascular systems, oxazolazepam caused slight hypotension and depression of heart rate in larger doses but no significant effects on respiration, ECG and responses to autonomic drugs. These effects were weaker than those by chlordiazepoxide. On isolated organs, oxazolazepam exhibited more effect than chlordiazepoxide. Other effects, such as miosis, hypothermia, constipation and physical dependence liability were less demonstrated by oxazolazepam than by chlordiazepoxide. Emetic, antiinflammatory and diuretic actions were not seen by these drugs. Subacute toxicity by oxazolazepam for 5 weeks was definitely less than by chlordiazepoxide.