Abstract
Epinephrine and norepinephrine were injected into the femoral vein at a constant speed to compare the pressor effect before and after administration of digitoxin in dogs anesthetized with pentobarbital. It was shown that blood pressure rise caused by epinephrine and norepinephrine was enhanced after dogs were saturated with digitoxin. The enhancement of pressor response by digitoxin became more significant after atropinization. Pressor response to vasopressin, on the other hand, was not influenced by digitoxin administration. From these results obtained, a possible mechanism was discussed on the potentiation of catecholamine action by cardiac glycosides.
