Abstract
It has been confirmed that bacterial pyrogen could be inactivated by treatment of a surfactant deoxycholate (DOC). We have studied on the mechanism pharmacologically, and the following results have been obtained; 1) Bacterial pyrogen was inactivated from 0.125 % of DOC. 2) DOC did not show any inactivation in vivo. 3) DOC did not inhibit the release of leucocytic pyrogen (LP). 4) Respiration of polymorphonuclear leucocytes (PMN) did not be inhibited by DOC in vitro. 5) Vascular permeability of LP was not influenced by DOC. 6) DOC showed little heamolytic effect, but it was inhibited by addition of serum, but the pyrogenic response of bacterial pyrogen was markedly increased by injection of saponin.
