Folia Pharmacologica Japonica
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
Relationship between ceruloplasmin and serotonin (5-HT)
1. Pigment formation from 5-HT
Atsuko MINAMIDATE
Author information
JOURNAL FREE ACCESS

1971 Volume 67 Issue 1 Pages 1-8

Details
Abstract
The present study was undertaken in order to examine whether ceruloplasmin, tyrosinase and AgNO3 change 5-HT into the pigment in vitro. The effects of 2, 3-Dimercaptopropanol (BAL) and α-MSH on the pigment formation from 5-HT was also studied. As a comparative study, the pigment formation from noradrenaline was also studied. 1) When noradrenaline was incubated with tyrosinase, the browish black pigment was formed. BAL inhibited this pigment formation, but α-MSH did not affect it. 2) The incubation of 5-HT with tyrosinase, α-MSH, or with both of them did not produce the pigment. 3) When 5-HT was incubated with AgNO3 or with ceruloplasmin, the brown or the brownish black pigment was formed from 5-HT respectively. BAL inhibited the both types of pigment formation from 5-HT. α-MSH had no effect on the pigment formation from 5-HT by ceruloplasmin.
Content from these authors
© The Japanese PharmacologicalSociety
Next article
feedback
Top