Abstract
Cardiovacular actions of Salbutamol in dogs were compared with those of Isoproterenol. Both drugs exhibited positive inotropic, chronotropic and peripheral vasodilating effects due to β-adrenergic stimulation.
Vasodilating effect of Salbutamol was 10 to 30 times less potent as that of Isoproterenol, while cardiac effect of the former was approx. 30 to 60 times less potent than that of the latter.
Qualitative differences were also suggested between cardiovascular actions of Salbutamol and Isoproterenol; i.e., (1) Positive inotropic action of Salbutamol was not potentiated even in the failing heart. (2) Salbutamol exerted no α-adrenergic stimulating action.
