Abstract
The intravenous, intraperitoneal, subcutaneous and oral acute toxicities of thiotic acid were investigated in Sprague-Dawley rats. The minimal lethal dose of the drug was 150mg/kg after intravenous administration.
One and six months toxicity tests using Sprague-Dawley rats were carried out with subcutaneous doses of 8, 16, 32, 64 and 125mg/kg. In these tests, the minimal lethal dose of thioctic acid was 125mg/kg. This was about one half of its LD50. Abnormal changes related to the drug were not observed in systemic signs, values of laboratory tests and histopathological findings.
