Pharmacological studies of a new minor tranquilizer dipotassium chlorazepate (7-chloro-1, 3-dihydro-2-oxo-5-phenyl-1H-1, 4-benzodiazepine 3-carboxylic acid monopotassium salt monopotassium hydroxide)

Report 1: Central actions

Abstract

A comparative study on the central inhibitory action of Dipotassium chlorazepate (CAP) and Diazepam was performed. The EEG and evoked potential were studied electrophysiologically in the neocortex and limbic system, and comparative studies on the antagonism against various convulsants or central stimulants were also performed. The above comparative studies of the two drugs have found CAP exhibiting a wider range of inhibition than Deazepam. As for the intensity of inhibition, in general, Diazepam was found to be a little stronger than CAP.