Abstract
Influence of p-sulfate on the analgesic effect and acute toxicity of aminopyrine was studied with the following results:
1) Analgesic effect of o-, m- and p-sulfate was not observed in the pressure and acetic acid method.
2) In the pressure and acetic acid method, p-sulfate markedly augmented the analgesic effect of aminopyrine (p. o. administration).
3) The effect of simultaneous use of p-sulfate on the toxicity of aminopyrine was increased more than the toxicity of aminopyrine alone.
4) The analgesic effect of aminopyrine was always augmented out of relation to the dose of p-sulfate.
5) Analgesic effect and acute toxicity of phenacetin, NAPAP, morphine and acetyl salicylic acid was not augmented by p-sulfate.
