Abstract
Treatment of mice with doxepin up to 10 days did not result in a demonstrable tole-rance to the inhibitory effect on spontaneous motor activity. While mice or rats were forced to drink doxepin solution for 30 days or after abrupt withdrawal, abnormal behavior ascribable to physical dependence was not observed. Doxepin did not sup-press abstinence signs which were elicited in barbital dependent mice. Based on these results, it may be concluded that this compound does not have tolerance and physical dependence producing liability.
