Abstract
Studies on the absorption, tissue distribution, metabolism and excretion of Mendon (14C (5)-labeled) were carried out. Results are as follows: The blood level reached the highest within approx. 1hr after oral administration, with a rapid decline thereafter, and only a trace was observed after a lapse of 21hr. One hr after oral administration, peak tissue levels of 14C were observed in both mice and rats. The levels were higher in the liver and kidneys, but the level in the brain was almost as low as that in the blood. In a rabbit, oxazepam and its conjugated form were found mostly in the urine as one of the metabolites of Mendon. The non-changed compound (Mendon), nordiazepam, its conjugated form plus a few unknown compounds were however, also observed. In rats, excretion generally took place within the intestinal tract, while in rabbits, it was through the urinary tract.
