Pharmacological studies on a new analgesic drug 1-(m-methoxyphenyl)-2-dimethylaminomethyl cyclohexanol (1) hydrochloride (K-315)

(3rd report) Relationship between monoamine in brain levels and analgesic action of K-315 in mice

Abstract

K-315 in an effective analgesic dose did not vary monoamine levels (nor-adrenaline, dopamine and 5-hydroxytryptamine) in mouse brain. The analgesic action of K-315 was potentiated by cocaine, but not modified by tetrabenazine and p-chlorophenylalanine, though lowered by reserpine and α-methyltyrosine. K-315 was not included in the same category as the other 4 analgesics (morphine, pethidine, dihydrocodeine and aminopyrine), regarding modification of analgesic effects due to variation of monoamine contents in the brain.