Effects of Vitamin B₁, B₆ and B₁₂ complex on the regeneration of the peripheral nerve and muscle receptor in cats

Abstract

Tibial nerve of adult cats was cut at the level of the popliteal fossa and the epineurium of the cut ends was sutured immediately after the cutting with the aid of special rings. Vitamin B₁, B₆ and B₁₂ complex (B₁, 5mg/kg, B₆, 5mg/kg and B₁₂, 50γ/kg) were injected i. m. daily for about 80 days, and the effects on nerve regeneration were investigated and compared with components. Greater effects of vitamin B₁, B₆ and B₁₂ complex than those of its components were as follows. 1) Gastrocnemius muscle tension. 2) Gastrocnemius muscle wt. ratio. 3) Nerve connection of the gastrocnemius muscle spindles and Golgi tendon organs. 4) Decubital ulcer and depilation (greater in decubital ulcer). In the soleus muscle tension and wt. ratio, no such superior effects were observed. The components of vitamin B complex (B₁, B₆ and B₁₂) did not differ significantly in muscle tension, muscle wt. ratio, decubital ulcer and depilation.