Abstract
Activities of various diuretics on experimental nephrotic rats (NER) were compared to those. of normal rats (NWR) with the following results. Spironolactone showed no diuretic activity on NWR but did show a natriuretic effect on NER. Triamterene showed a more potent potassium sparing effect on NER than on NWR and Na+/K+ ratio in the urine was the highest of all diuretics tested. Methyclothiazide showed a most potent diuretic activity on NER and also decreased the excretion of protein and enzymes into the urine of nephrotic animals. Hydrochlorothiazide had a strong chloriuretic effect and decreased proteinuria. Furosemide and Clorexolone had almost the same potent diuretic activity on NER and NWR. Acetazolamide decreased the natriuretic effect and increased the kaliuretic effect on NER. Melarulide showed no diuretic activity but did show an increase of proteinuria on NER. Ethacrynic acid did not have diuretic effects eithers on NER or on NWR. To elucidate the property of diuretics, the experimental rats utilized herein proved adequate.
