Abstract
Interactions of glucofuranoside (GF) and vasoactive agents on isolated strips of inferior caval, femoral, colic and portal veins and femoral arteries from rabbits, dogs, miniature pigs and monkeys (Maccaca irus) were investigated. The resting tension of the vein strips from rabbits, dogs and miniature pigs was not influenced or was only slightly reduced by GF (2×10-7 to 2 × 10-4 M). In veins from one of 4 monkeys, GF caused contraction. Dose-contractile response curves of serotonin, noradrenaline, histamine, angiotensin, K+ and Ba++ were moved right and downwards by GF (2 × 10-6 to 2 × 10-4 M) in a dose-dependent manner, the attenuation of the response to K+ and Ba++ being appreciably greater than that with the other agents. Contractile responses of isolated strips of rabbit portal veins to transmural neural stimulation were also inhibited by GF. In portal vein strips depolarized by K+, the Ca++-induced contractions were decreased by GF, the decrease being greater than thatby papaverine. It appears that GF attenuates the contractile response to vasoactive agents, mainly by interference with influxes of Ca++ across cell membranes. There was no definite tendency for GF to induce greater inhibition in the response of veins than that of arteries.
