Abstract
Effects of naproxen on wet weight of granuloma, exudate volume and the amount of connective tissue components in granuloma were investigated using a proliferative inflammatory model in filter paper-implanted rats. The drug remarkably inhibited granuloma formation and exudate accumulation and strongly decreased 0.15 M NaCl extractable contents of total mucopolysaccharide, acid mucopolysaccharide, glycoprotein and non-collagen protein in granuloma, although this drug caused only a weak decrease of the total contents of these components. As a result, the ratio of soluble content to the insoluble one of these components was reduced. On the contrary, the collagen content was increased, that is this drug facilitated the fibrization of granuloma tissue. In these tests, the efficacy of naproxen was comparable to 1/4 the dose of indomethacin. Benzydamine HCl and prednisolone had a different mode of action, compared with that of naproxen : Benzydamine HCl failed to inhibit granuloma formation and exudate accumulation. Prednisolone did not change the ratio of soluble fraction to an insoluble one of granuloma ground substances. These results suggest that like indomethacin, naproxen may potentiate the structural stability of granuloma tissue.
