Abstract
In a previous paper, ketoprofen, 2-(3-benzoylphenyl)-prop ionic acid, was found to have similarly potent anti-inflammatory and analgesic activities to that of indomethacin. In this paper, the general pharmacological actions of ketoprofen were tested in order to investigate whether or not. the compound had other valuable actions, side effects and indirect anti-inflammatory actions. Ketoprofen was proven to exert slightly sedative and depressive effects on the central nervous system, but the activity was less than that of indomethacin and did not appear at anti-inflammatory doses. Though it decreased urine volume and electrolytes in urine, this property was found not only in ketoprofen, but also in all other acidic nonsteroid anti-inflammatory agents. Ketoprofen showed no other significant pharmacological activities e.g. on the respiratory and cardiovascular system, on the autonomic nervous system, on the smooth and skeletal muscles, on the sugar leveland coagulation in blood and on the local irritation. Moreover, the responses of catecholamine, acetylcholine, histamine, bradykinin, 5-HT and BaCl2 were not affected by ketoprofen. Therefore, it was found to have no antagonistic properties regarding transmitters or chemical mediators. From the above results, it may be considered that ketoprofen does not indirectly exert anti-inflammatory action due to other pharmacological actions, but rather directly potent anti-inflammatory action and has fewer side effects.
