Folia Pharmacologica Japonica
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
Studies on arsenic metabolism (XII). Effect of polypeptone and polytamine on arsenic accumulation in certain organs and effect on excretion.
Shunkichi TAMURAHiroshi MAEHASHIShigeru NOZAKIReiko MIZUKAMI
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1974 Volume 70 Issue 6 Pages 831-836

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Abstract
When As2O3 was added to the diets, the content of As2O3 in organs decreased according to the amount of milk as the constituent. In the previous study, it was found that this factor was related to the casein. The present study was carried out to ascertain whether polypeptone and polytamine show the same effect or not. Male albino rats of Wistar strain (Tamura, 1950) by closed colony, weighing about 100 g were used. The experimental groups were fed a cereal diet with 20% of polypeptone or polytamine and As2O3 with a 650 ppm. The control group was fed cereal and As2O3 with a 650 ppm. There was no statistically significant difference concerning gain in body weight among the groups. There was no difference in the arsenic content in feces. The arsenic content in the urine and kidney of polypeptone + As group was higher than the other groups, the arsenic content in the brain of polypeptone + As group was lower than the others and the arsenic content in the liver and spleen of polytamine + As group was higher than the others.
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