Abstract
Four novel antitumor amino acid related compounds were labeled with 14C and the distribution was studied in mice. *A-91 was excreted into the bile, and a high level of radioactivity in the blood was maintained throughout the 24 hr of experiment. A high radio-activity was seen in the liver, lung, kidney, urinary bladder, and tumor. *A-145 was rapidly distributed to each tissue from the blood, especially to the pancreas, salivary glands, gastrointestinal tract, tumor, and other growing and secreting tissue. *A-192 was excreted into the bile and a high level of radioactivity was seen in the blood. A high radioactivity was detected in the liver, lung, kidney, uterus, ovary, and tumor, followed by a reduction paralleled with a concentration in the blood. *A-192 was rapidly excreted into the urine and very little radioactivity was observed in almost all organs and tissues, except for the central nervous system. *Cyclophosphamide was also rapidly excreted into the urine and bile, but only slight activity was observed in most organs. *Tryptophan, *isoleucine, *valinethese three had the same distribution patterns, and were incorporated into the growing and secreting tissues, pancreas, salivary glands, gastrointestinal tract, tumor, etc.
