Abstract
The toxicity of drugs was determined using embryonic skin and muscle from humans (Flow 1, 000). The dosage causing a 50% inhibition culture growth (ID50) and minimum concentration, caused by the detachment of the cell from the vessel wall, were determined. ID50 values of ibuprofen, naproxen, Y-5554, dichlofenac and aminopyrine were found to be 150, 320, 220, 110 and >500 μg/ ml respectively. Minimum concentration, caused by the detachment of the from the vessel wall, was as follows: ibuprofen 250, naproxen 250 ?? 500, Y-5554 250 ?? 500, dichlofenac 62.50 ?? 125 and aminopyrine 1, 000 ?? 2, 000 μg/ml respectively.
