Abstract
An in vivo study was made on the effect of linoleic acid hydroperoxide on the formation of lipid peroxide in rat liver mitochondria, and results are as follows: There were no changes in contents of lipid peroxide and total sulfhydryl in rat liver mitochondria after daily administration of linoleic acid hydroperoxide (10 mg/kg, i.p.) for 3 or 7 days. Changes in the fatty acid composition in plasma and liver after i.p. administration of linoleic acid hydroperoxide for one week were not observed as compared to that of control animals. In addition, no appreciable change was found in the fatty acid composition of phosphatidylserine and phosphatidylinositol in liver mitochondria from rats treated with linoleic acid hydroperoxide. After treatment with linoleic acid hydroperoxide for 3 days, content of plasma triglycerides increased, but no effect was observed in liver triglycerides. However, plasma triglycerides returned to the control level and triglycerides in liver increased by treatment with linoleic acid hydroperoxide for one week. Free fatty acids decreased in plasma but not in the liver from rats treated with linoleic acid hydroperoxide for 3 or 7 days.
