Effects of 5-(o-chlorophenyl)-1-methyl-7-nitro-1, 3-dihydro-2H-1, 4-benzodiazepin-2-one (ID-690) as compared to nitrazepam on the sleep-wakefulness cycle in cats

Abstract

ID-690 was given at doses over 0.3 mg/kg, and increase in state of arousal and decrease in state of slow wave sleep were observed. Nitrazepam at doses over 1.0 mg/kg revealed similar effects. These agents increased incidences of paradoxical sleep at a low dose of 0.03 mg/kg. When ID-690 was given at doses over 0.3 mg/kg, the number and duration of incidences of paradoxical sleep decreased. Nitrazepam at doses over 0.1 mg/kg had a similar depressive effect on paradoxical sleep. These results suggest that these benzodiazepines have, dose-dependently, both facilitative and depressive actions on paradoxical sleep, and that the dose of these agents which affects arousal is not always the same as that which affects paradoxical sleep.