Abstract
Influence of inflammation on prostaglandin metabolism in rat abdominal skin was studied. Prostaglandin F2α content was determined by the radioisotope dilution method. Prostaglandin F2α content in rat abdominal skin was increased by thermal burn and application of 2, 4-dinitrochlorobenzene. The incorporation of 3H-arachidonic acid into prostaglandin F2α in rat abdominal skin was not increased by inflammation. Indomethacin caused a significant reduction of prostaglandin F2α content. These results suggest that the prostaglandin may play an important role in the inflammatory process of rat skin.
