Influence of estrogen on the delayed action of prostaglandin F_2α, on the rat uterine contraction

Abstract

Responsiveness of the rat uterus on the day of estrus to PGE₂, PGFF_2α and oxytocin was increased by administration of PGF_2αi.p.24 hours prior to the experiments, but that of the uterus on the day of diestrus was not altered by the same treatment.The delayed action of PGF_2α was not observed in the uterus of ovariectomized rats, but was observed in the uterus of estrogen treated rats. The delayed action of PGF_2α was not evident in either the vas deferens or the intestine of the rat.