Pharmacological studies on oxatomide: (6) Effect on the peripheral organs

Abstract

The effects of oxatomide, an anti-allergic drug, on the cardiovascular, digestive and autonomic nervous systems were investigated, and the following results were obtained: Intravenous administration of oxatomide, at doses of 1 mg/kg or more, lowered arterial blood pressure, decreased heart rate, increased femoral blood flow, and depressed the gastrointestinal and uterine movement in anesthetized dogs, rabbits and rats. In in vitro experiments, oxatomide inhibited spontaneous movements of isolated rabbit ileum, isolated guinea pig atrium and isolated rat uterus at considerably high concentrations of 10^-6M or more. The antagonistic activity of oxatomide for histamine in isolated guinea pig ileum and trachea was observed at concentrations of 3×10^-8M or more. Oral administration of oxatomide, however, had no significant influence on the cardiovascular, digestive and autonomic nervous systems and urogenital organs, at doses up to 100 mg/kg. The antigenicity of oxatomide was studied with immunological procedures such as active anaphylactic shock, passive cutaneous anaphylaxis and passive hemagglutination test in guinea pigs, rats and mice. In these tests, neither anaphylactic shock nor allergic reaction was observed. From these results, it is suggested that oxatomide shows little effect on peripheral organs at a dose which elicites the anti-allergic actions and may have no antigenicity to experimental animals.