Abstract
The effects of suloctidil, an antispasmodic agent, on the femoral, renal, superior mesenteric, common carotid and vertebral blood flows were compared with those of papaverine and cinnarizine using electromagnetic flow meters in pentobarbital anesthetized dogs. In ix. administration, the peripheral vasodilating action of suloctidil, papaverine and cinnarizine dose-dependently occured from the dose of 0.1 mg/kg, and the order of their potencies in blood flow increase was vertebral ?? femoral ?? common carotid ?? mesenteric artery. However, the renal blood flow decreased byi.v. administration of suloctidil and papaverine. I.a. administration (1-100 μg/kg) of suloctidil, papaverine and cinnarizine dose-dependently increased femoral and common carotid blood flows. I.a. administered suloctidil and papaverine caused a transient increase of renal blood flow followed by a slight decrease. Suloctidil-induced increase of femoral blood flow was not affected by the pre-treatment with atropine, propranolol or diphenhydramine. Thus, suloctidil may cause direct vasodilation to increase regional blood flow, and its influence on the various blood flows is roughly similar to those of papaverine and cinnarizine.
