Effects of somatostatin and its analogue on gastric secretion

An application of the secretagogues to gastric secretion

Abstract

A simple technique to examine the effects of drugs on the gastric secretion response to the secretagogues without anesthesia was shown in this paper. The administration of bethanechol (1mg/kg, s. c.), histamine (15mg/kg, s. c.) or pentagastrin (0.25mg/kg, i. p.) significantly increased the gastric volume and the total acid output in the pylorus-ligated rat. These responses to the secretagogues were inhibited by N-butylscopolamine, urogastrone or cimetidine dose-dependently. N-butylscopolamine (0.5mg/kg, i. p.) inhibited the response to bethanechol but not that to pentagastrin or histamine. Cimetidine (5mg, kg, i. p.) inhibited not only the response to histamine but also the acid response to bethanechol or pentagastrin. Urogastrone (5mg/kg, i. p.) inhibited the response to these three secretagogues. The ratio of the total acid output to the gastric volume was also examined in each of the cases. Somatostatin (0.1mg/kg, i. p.) inhibited the response to pentagastrin, but not that to bethanechol or histamine. On the other hand, an analogue of somatostatin (SS-1; 0.1mg/kg, i. p.) inhibited the response to bethanechol but not that to pentagastrin or histamine.