Abstract
We report a case of 63-year-old man with quadruple cancers of the esophagus, stomach, duodenum and sigmoid colon. All cancers were treated with curative endoscopic resection. At first, a cancer in the sigmoid colon was treated by endoscopic mucosal resection (EMR), then a cancer in the duodenum was treated by endoscopic submucosal dissection (ESD). After that, a cancer in the stomach was treated by endoscopic mucosal resection using ligating device (EMRL), then two heterochronous cancers in the esophagus were treated by ESD. He is alive and well 4 months after the last esndoscopic resection. The incidence of double cancer has recently increased, but quadruple cancers remain extremely rare. Quadruple cancers in the gastrointestinal tract, and head and neck area were reported as very rare cases in Japan. This is the first report to treat all quadruple cancers in the gastrointestinal tract endoscopically. Multiple cancers in the gastrointestinal tract, and head and neck area occur more often than in other organs, mainly because of risk factors such as smoking and alcohol consumption. So we think periodic endoscopic follow up is necessary even for patients with cancer who had been treated curatively.
