THREE CASES OF COLLAGENOUS COLITIS WITH LONGITUDINAL ULCERS

Abstract

We report herein three cases of collagenous colitis with longitudinal ulcers. Longitudinal ulcers were first observed in the sigmoid and descending colon on colonoscopy performed due to chronic diarrhea and loose stool. Biopsy from the ulcer revealed diffuse proliferation of the subepithelial collagen band, and the diagnosis of collagenous colitis was made. All patients had taken lansoprazole for 5 to 16 months prior to examination, and this was believed to be a possible cause of the pathology. In one patient, discontinuation of lansoprazole resulted in immediate improvement in diarrhea. In the two patients who continued taking lansoprazole, symptoms persisted for 2 to 8 months then improved without discontinuation of the drug.