Abstract
An esophageal submucosal tumor (SMT) was discovered in 50 years-old male and was diagnosed as leiomyoma by strip biopsy. The tumor gradually expanded, and squamous cell carcinoma (SCC) emerged just above the leiomyoma. We performed ESD, for both the SMT and esophageal carcinoma. The SMT was positive for SMA, and negative for s100, vimentin, CD34 and c-kit. Pathological examination revealed low-high grade dysplasia and carcinoma in situ (ml) on the leiomyoma. Although chronic inflammation might cause esophageal dysplasia, the findings in our case suggested that mechanical stress caused by the SMT induced chronic inflammation, leading to the development of carcinoma.