Abstract
A 31-year-old woman was referred to our department because of dysphagia and food impaction for more than 6 years. Upper gastrointestinal endoscopy revealed a marked stricture at the esophagogastric junction without tumor. Endosonography revealed mucosal thickening of the esophagus and pathological examination of biopsied specimens showed marked infiltration of eosinophils (≥100/high-power field, HPF) and microabscess in the esophageal epithelium. Blood chemistry revealed an increase in the number of peripheral eosinophils and total immunoglobulin E (IgE) levels, and patch tests were positive for foods, including eggs and fish. The diagnosis of eosinophilic esophagitis was confirmed on the basis of the clinical symptoms and endoscopic and pathological findings. The patient was started on fluticasone swallowing therapy. Improvement in the symptoms, stricture, and histology was noted 2 months after the topical steroid therapy.
