GASTROINTESTINAL HEMORRHAGE DUE TO SORAFENIB IN TWO PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA

Abstract

Two patients who had gastrointestinal hemorrhage due to Sorafenib are presented. In case 1, bloody stools occurred within 1 week after the Sorafenib treatment. The endoscopic findings revealed edematous and reddish changes in the duodenal mucosa. In case 2, bloody stools occurred 1 month after the Sorafenib treatment. Colonoscopic findings indicated similar mucosal change in the colon. The hemorrhagic points were difficult to detect in both cases. However, a quick improvement in the bloody stools after stopping Sorafenib intake suggested that the gastrointestinal hemorrhage was associated with Sorafenib treatment. The endoscopic mucosal findings in both cases would probably be characteristic of patients with gastrointestinal hemorrhage due to Sorafenib.