Abstract
FOSFOMYCIN (FOM) is usually used for enteric infection in addition to the new quinolone antibiotics. We report herein on a case of antibiotic-associated hemorrhagic colitis (AAHC) induced by oral administration of FOM. A-30-year-old man with abdominal pain and bloody stool was admitted to our hospital. Antibiotic therapy with FOM 1,500 mg/day had been started for enterocolitis-associated diarrhea at another clinic 4 days prior to visiting our hospital. Abdominal CT scans visualized edematous wall thickness between the cecum and sigmoid colon. Colonoscopy showed an erosive lesion with mild stenosis of the ascending colon. Klebsiella oxytoca was detected in the stool culture examination. AAHC and enterohemorrhagic Escherichia coli infection were considered as a differential diagnosis, so we stopped oral administration of FOM and prescribed Levofloxacin (LVFX) together with an intestinal probiotic remedy. Eight days later, the symptoms had disappeared and the abnormal CT findings had improved. A drug-induced lymphocyte stimulation test (DLST) against FOM showed highly positive findings compared with controls.
