THE EFFICACY OF MOVIPREP AS A PREPARATION FOR COLONOSCOPIC EXAMINATION

Abstract

Introduction : We analyzed the efficacy of a reduced volume of Moviprep^® (Ajinomoto, Tokyo, Japan) as a highly concentrated polyethylene glycol (PEG) solution.
Methods : This study was a prospective single-arm clinical study. We analyzed patients who were scheduled for colonoscopic examination at the Kyoto Prefectural University of Medicine from July 2013 to December 2013. All patients took a commercial special diet for the examination and sodium picosulfate the day before the examination. The patients took one liter of Moviprep^® and 0.5 liter of water on the day of the examination. We compared the preparation time and grade of endoscopic cleansing, and results of blood examination before and after taking Moviprep^®, with those in 122 patients receiving the standard PEG solution.
Results : One hundred eleven patients were enrolled in the Moviprep^® group and analyzed. The cleansing time of the Moviprep group was significantly shorter than that of the standard PEG group (165±53 mins vs. 192±72 mins) (p<0.05). In the Moviprep^® group, good endoscopic cleansing was achieved in the right-sided colon in 85.8% and in the left-sided colon in 91.5%. With respect to blood examination, the chloride level was lower after taking Moviprep^® compared to that before taking Moviprep^® in patients without disorder of renal function. There were no significant differences in results of blood examination in patients with disorder of renal function between before and after taking Moviprep^®.
Conclusions : Our study showed that bowel cleansing was efficient with a reduced volume of Moviprep^® using a special diet and sodium picosulfate.