Abstract
“Helicobacter pylori-uninfected gastric cancer” that develops from H. pylori-uninfected gastric mucosa is rare. “H. pylori-uninfected gastric cancer” seems to represent gastric adenocarcinoma of fundic gland type which Yao et al. proposed for intestinal-type gastric cancer, and early signet ring cell adenocarcinoma for the diffuse type.
Gastric adenocarcinoma of fundic gland type develops primarily in the body of the stomach and is a tumor with low grade of atypism that is mainly composed of gastric-type cancer immunohistologically ; however, this tumor tends to invade the submucosa at an early stage. Therefore, a small submucosal lesion that is observed endoscopically in the gastric mucosa of the body of the stomach without atrophic changes should be tested further for potential cancer. On the other hand, it seemed that signet ring cell adenocarcinoma which was relatively frequently detected in uninfected gastric mucosa was representative of diffuse gastric cancer, and a small discolored region in the body of the stomach that is observed endoscopically should be tested further. In the near future, many cases of “H. pylori-uninfected gastric cancer” will accumulate, and they should be analyzed clinically and genetically.
