A CASE OF EARLY GASTRIC CARCINOMA WITH LYMPHOID STROMA RESECTED BY ENDOSCOPIC SUBMUCOSAL DISSECTION

Abstract

A 57-year-old man visited our hospital for treatment of an early gastric cancer, which had been detected by screening endoscopy. Endoscopic examination revealed that the lesion was depressed, about 20 mm in diameter, and located at the posterior lesser curvature of the middle body of the stomach. A biopsy specimen revealed a poorly differentiated adenocarcinoma with profusely infiltrating lymphoid cells. Magnifying endoscopic examination of the lesion revealed a microvascular pattern similar to that of an undifferentiated adenocarcinoma. The lesion was resected en bloc by endoscopic submucosal dissection (ESD). Histological examination revealed a gastric carcinoma with lymphoid stroma (GCLS) limited to the mucosa. In situ hybridization for Epstein-Barr virus-encoded small RNA was positive. We report on this rare case of GCLS resected by ESD and discuss the relevant literature.