2016 Volume 58 Issue 12 Pages 2399-2404
An 84-year-old woman who used minodronate for two years visited our institute with chest discomfort and dysphagia. Esophagogastroduodenoscopy revealed ulcerations in the anal end of an esophageal diverticulum and distal esophageal mucosa. She was suspected of having esophageal ulcers induced by minodronate. Administration of minodronate was stopped and treatment with lansoprazole and sodium alginate was started. The ulcers rapidly improved and no recurrence was observed. Although there have been a few cases of esophageal ulcers induced by bisphosphonates, no case was induced by minodronate in the presence of an esophageal diverticulum.