Abstract
A 63-year-old man with multiple myeloma was referred to our hospital with the complaint of melena. Upper gastrointestinal endoscopy showed a huge submucosal tumor with redness and erosion and he was diagnosed with gastric invasion of multiple myeloma by examination of biopsy specimens. The patient required a large volume of blood transfusion, and the tumor was treated with radiation therapy 40 Gy. After the therapy, the tumor drastically decreased in size on follow-up endoscopy and the melena disappeared. Gastric invasion of multiple myeloma is very rare. Our case is the first case in Japan in which radiation therapy was ascertained to be effective for gastric invasion of multiple myeloma.
