2017 Volume 59 Issue 2 Pages 171-176
A 64-year-old woman who had undergone thyroidectomy and chemoradiation therapy for diffuse large B-cell lymphoma of the thyroid ten years ago, was admitted to our hospital with the complaint of epigastralgia. Upper and lower endoscopy revealed multiple ulcerative lesions on the duodenum, ileum, and colon. The biopsy specimen showed that atypical lymphocytes infiltrated the submucosa with various inflammatory cells. Irregular ulcerative lesions were also present on her oropharynx. Atypical lymphocytes were positive for Epstein-Barr virus (EBV)-encoded small RNA-1. Therefore, she was diagnosed with EBV-positive intestinal lymphoma. It was speculated that her immunodeficient state due to the previous chemoradiation therapy reactivated EBV and caused the onset of intestinal lymphoma.
