CLINICAL AND ENDOSCOPIC FEATURES OF GASTRIC ADENOCARCINOMA OF FUNDIC GLAND TYPE (CHIEF CELL PREDOMINANT TYPE)

Abstract

Gastric adenocarcinoma of fundic gland type (chief cell predominant type) (GA-FG) is a variant of gastric adenocarcinoma with chief cell differentiation. GA-FG is still rare, and its clinical features are not well known. The most characteristic endoscopic features were whitish color, dilated surface vessels of the tumor and subepithelial or submucosal tumor-like appearance. Helicobacter pylori infection was identified in about 40％ of cases, and this rate is lower than that among usual gastric cancer cases. Most of the lesions were found in the upper or middle portion of the stomach with non-atrophic gastric mucosa. Most detected lesions have been very small in size, and they were mainly treated by endoscopic submucosal dissection. Submucosal invasion was identified in more than half of the resected lesions despite their small size, and this is one of the distinctive pathological findings of GA-FG.