Ramucirumab使用中に出血を来した小腸angioectasiaに対し小腸内視鏡で止血を行った１例

高田 智司; 桐山 正人; 稲田 悠記; 東 友理; 金本 斐子; 東 勇気; 岩田 啓子; 月岡 雄治; 辻 宏和

doi:10.11280/gee.60.2387

A CASE OF HEMORRHAGIC SMALL BOWEL ANGIOECTASIA DURING RAMUCIRUMAB MONOTHERAPY TREATED BY SINGLE-BALLOON ENDOSCOPY

Satoshi TAKADA , Masato KIRIYAMA, Yuki INADA, Yuri HIGASHI, Ayako KANAMOTO, Yuki HIGASHI, Keiko IWATA, Yuji TSUKIOKA, Hirokazu TSUJI

Author information

Satoshi TAKADA Corresponding author
Department of Surgery, Kurobe City Hospital.
Masato KIRIYAMA
Department of Surgery, Kurobe City Hospital.
Yuki INADA
Department of Internal Medicine, Kurobe City Hospital.
Yuri HIGASHI
Department of Surgery, Kurobe City Hospital.
Ayako KANAMOTO
Department of Surgery, Kurobe City Hospital.
Yuki HIGASHI
Department of Surgery, Kurobe City Hospital.
Keiko IWATA
Department of Surgery, Kurobe City Hospital.
Yuji TSUKIOKA
Department of Surgery, Kurobe City Hospital.
Hirokazu TSUJI
Department of Internal Medicine, Kurobe City Hospital.

JOURNAL FREE ACCESS FULL-TEXT HTML

2018 Volume 60 Issue 11 Pages 2387-2392

DOI https://doi.org/10.11280/gee.60.2387

《掲載論文》vol.60 No.11 p.2355

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Abstract

An 80-year-old man who was administered ramucirumab (RAM) as a second-line chemotherapy for advanced gastric cancer with lung metastasis, complained of melena and anemia after eight courses of chemotherapy. Capsule endoscopy revealed bleeding from the upper jejunum, and we diagnosed hemorrhagic small bowel angioectasia on subsequent single-balloon endoscopy. The anti-angiogenic effect of RAM may inhibit hemostasis. The bleeding was controlled by precise endoscopic intervention. Careful follow-up is important because of the high rebleeding rate of small intestinal vascular lesions including angioectasia.

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