FECAL MICROBIOTA TRANSPLANTATION VIA COLONOSCOPY

Abstract

Clostridium difficile infection (CDI), which typically occurs after the administration of antibiotics, can become severe and result in death of elderly patients and immunocompromised patients. Fecal microbiota transplantation (FMT) is attracting attention because of its high efficacy against CDI, especially refractory and recurrent CDI. FMT is a treatment in which healthy donor stool is administered directly to the digestive tract of patients using endoscopy or nasogastric tubes. Recently, oral administration of encapsulated feces has also been reported. Moreover, there are few serious adverse events, and the efficacy rate against CDI reaches about 90％. On the other hand, the effectiveness of FMT has not yet been established for inflammatory bowel diseases and other disorders in which the alteration in gut microbiota has been reported to be involved in their pathogenesis.