A CASE OF WELL-DIFFERENTIATED TUBULAR ADENOCARCINOMA WITH INTESTINAL PHENOTYPE AT THE GASTRIC ANTRUM OF A PATIENT WHO WAS NOT INFECTED WITH HELICOBACTER PYLORI

Abstract

A 40-year-old man was referred to our hospital for detailed examination of a gastric neoplasm. Esophagogastroduodenoscopy (EGD) revealed a flat elevated lesion of 10 mm in diameter in the lesser curvature of the antrum. Atrophy of gastric mucosa was not observed. Endoscopic submucosal dissection (ESD) of the lesion was performed. Histopathological examination revealed the lesion as a well-differentiated tubular adenocarcinoma that was confined to the mucosa with a clear resection margin. Immunohistochemical staining showed that the neoplasm was positive for CDX2 and CD10, and negative for MUC5AC and MUC6, which indicated that the lesion showed intestinal phenotype. Helicobacter pylori (HP) was negative in the histological examination, serum antibody test and urea breath test. The patient had no history of HP eradication therapy. This is a rare case of gastric cancer with intestinal phenotype in a patient who was not infected with HP.