2019 Volume 61 Issue 12 Pages 2610-2616
A 69-year-old male was diagnosed as having gastric disease at a nearby hospital and presented to our hospital for further evaluation of this disease. Esophagogastroduodenoscopy (EGD) showed multiple submucosal tumor-like polypoid lesions on the greater curvature of the gastric body. The biopsy specimens from the lesions revealed noncaseating granulomas in lamina propria mucosae. Interestingly, cells that were positive on immunostaining with the antibody against Propionibacterium acnes (PAB antibody), a possible pathogen of sarcoidosis, were detected in the granulomas. The patient was diagnosed with gastric sarcoidosis. EGD performed seven months later revealed a reddish depressed lesion of 13 mm in diameter with elevated margins near a granuloma on the greater curvature of the lower gastric body. We diagnosed Type 0-Ⅱc early gastric cancer and performed endoscopic submucosal dissection. The pathological examination revealed a p Type 0-Ⅱc, 15×8 mm, tub1＞tub2, pT1b (350μm), ly0, v0, UL＋, p HMX, p VMX. There are few reports of the coexistence of gastric sarcoidosis and gastric cancer, and this case showed interesting histological findings such as PAB antibody-stained cells in the granulomas. We report this case with reference to the literature.
